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Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
(BioMed Central Ltd, 2022-09-15)
Background: A novel series of thiazolidine-2,4-dione molecules was derived and their chemical structures were established using physiochemical parameters and spectral techniques (1H-NMR, IR, MS etc.). The synthesized ...
Synthesis, in vitro, and docking analysis of c-3 substituted coumarin analogues as anticancer agents
(Bentham Science Publishers, 2020-01-28)
Background: Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several ...
Synthesis and In Silico Studies of C-4 Substituted Coumarin Analogues as Anticancer Agents
(Bentham Science Publishers, 2020-06-29)
Background: Coumarin is a fused ring system and possesses the enormous capability of targeting various receptors participating in the cancer pathway. Coumarin and its derivatives were found to exhibit very rare toxicity ...