Browsing Human Genetics and Molecular Medicine-Research Publications by Title
Now showing items 209-228 of 256
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Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and technologies
(Editions de Sante, 2023-08-09)Microwave irradiation technology has a lot of applications in the field of food processing, organic synthesis, pharmaceuticals, and biomedical therapy. The basic mechanisms observed in microwave-assisted syntheses are ... -
Recent advances in the omics-based assessment of microbial consortia in the plastisphere environment: Deciphering the dynamic role of hidden players
(Institution of Chemical Engineers, 2023-06-10)Continuous disposal of plastic waste and its accretion in the environment is the biggest challenge the world has ever faced. Breaking its terrestrial bounds, plastic waste has now extended its outreach to aquatic territories ... -
Recent updates on the therapeutic potential of HER2 tyrosine kinase inhibitors for the treatment of breast cancer
(Bentham Science Publishers B.V., 2018)HER2 positive breast cancer is characterized by the low survival rate in the metastatic patients. Development of resistance and disease-relapse are the major problems associated with the currently available therapies for ... -
Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment
(2012)Background: GAD65 (Glutamic acid decarboxylase 65 KDa isoform) is one of the most important auto-antigens involved in Type 1 diabetes induction. Although it serves as one of the first injury markers of ?-islets, the ... -
Research advances in Apert syndrome
(Elsevier B.V., 2018)Apert syndrome is one of the several genetic syndromes associated with craniosynostosis, a condition that includes premature fusion of one or multiple cranial sutures. There has been significant clinical variation among ... -
Ring chromosome 22: A review of the literature and first report from India
(2012)Ring chromosome 22 [r(22)], a rare cytogenetic finding, has been described in nearly 70 cases to date. Cytogenetic investigations were carried out on a 5-year-old male child with microcephaly and intellectual disability. ... -
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
(Bentham Science Publishers B.V., 2017)Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ... -
Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs
(Academic Press, 2022-10-28)Despite advanced clinical and translational oncology research, mortality rates are still increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and ... -
Role of lncRNAs in the Development of Ischemic Stroke and Their Therapeutic Potential
(Springer, 2021-04-05)Stroke is a major cause of premature mortality and disability around the world. Therefore, identification of cellular and molecular processes implicated in the pathogenesis and progression of ischemic stroke has become a ... -
Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
(Springer, 2022-01-13)Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus ... -
Role of Omics in Migraine Research and Management: A Narrative Review
(Springer, 2022-07-07)Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors ... -
Role of p53 gene in breast cancer: Focus on mutation spectrum and therapeutic strategies
(Bentham Science Publishers B.V., 2018)TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression of various genes that are directly or indirectly under the ... -
Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke
(Springer New York LLC, 2017)In the present study, we evaluated the association of TLR4 and CD14 polymorphisms, i.e. C1196T and C-260T, respectively, with ischemic stroke (n?=?700), its subtypes and hemorrhagic stroke (n?=?300) in a South Indian ... -
Role of tRNA-Derived Fragments in Neurological Disorders: a Review
(Springer, 2022-11-09)tRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or mature tRNA, forming ... -
Safety and ethics in biotechnology and bioengineering: What to follow and what not to
(Elsevier Inc., 2017)Biotechnology and bioengineering are disciplines of science, which use knowledge of biological sciences and advanced technologies to generate new and useful products and processes for the benefit of society. The potential ... -
Serum Albumin Levels in Breast Cancer: Correlation with Overall Survival
(SciTechnol, 2017)Introduction: Albumin in an important biomarker that indicates malnutrition as well as inflammation. The aim of the study was to evaluate the albumin levels in breast cancer patients and its association with overall survival ... -
Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
(Frontiers Media S.A., 2019)Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported ... -
Shared and unique common genetic determinants between pediatric and adult celiac disease
(BioMed Central Ltd., 2016)Background: Based on age of presentation, celiac disease (CD) is categorised as pediatric CD and adult CD. It however remains unclear if these are genetically and/or phenotypically distinct disorders or just different ... -
Small regulatory molecules acting big in cancer: Potential role of mito-miRs in cancer
(Bentham Science Publishers, 2019)MicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs ...