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    Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic condition

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    Date
    2018
    Author
    Goyal, Sapna
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    Abstract
    Breast cancer has become the prevailing cause of death, so the research for their treatment has become advanced day by day. Breast cancer behaves differently in normoxic and hypoxic condition so does the anticancer drugs in both the condition in order to treat them. These drugs might have different effect on the expression of miRNAs in both normoxic and hypoxic conditions. In the present study, we evaluated the IC50 of three anticancer drugs-doxorubicin, ?-Amanitin, DCA on MDA-MB-231 and after treatment with these drugs, have checked the expression of miRNAs- let-7b and miR1275 in both hypoxic and normoxic condition by RT-PCR and results were analyzed by native PAGE
    URI
    http://210.212.34.21/handle/32116/1886
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    • Human Genetics and Molecular Medicine-Master Dissertation [19]
    • Master's [191]

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    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Initiatives by University Library 
    Central University of Punjab