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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
(Springer New York LLC, 2018)
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell ...
Ganoderic Acid A Targeting ?-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study
(Springer Berlin Heidelberg, 2018)
Wnt signaling pathways are the group of signaling transduction controlling the embryonic development, cell proliferation, cell migration, cell fate specification, and body axis pattern. Nuclear accumulation of ?-catenin ...
Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators
(Elsevier Ltd, 2018)
Ground breaking clinical therapeutic advances in the treatment of breast cancer (BC) is the introduction of selective estrogen receptor modulators (SERMs). We have expeditiously designed and synthesized indole-xanthendione ...
In silico screening and molecular interaction studies of tetrahydrocannabinol and its derivatives with acetylcholine binding protein
(Bentham Science Publishers B.V., 2018)
Background: Alzheimer’s disease (AD) is the fourth largest cause of death among people over 65 years of age. Accumulation of β-amyloid and cholinergic deficiency are two prominent pathological descriptions for AD.
Objective: ...
Transcriptome characterization and screening of molecular markers in ecologically important Himalayan species (Rhododendron arboreum)
(Canadian Science Publishing, 2018)
Rhododendron arboreum is an ecologically prominent species, which also lends commercial and medicinal benefits in the form of palatable juices and useful herbal drugs. Local abundance and survival of the species under a ...
Development And Characterization Of SSR Markers In Calotropis Procera
(Central University of Punjab, 2018)
Calotropis procera is a weed growing around the arid and semi-arid areas of the
tropical and subtropical regions. The species has the potential to replace cotton
and resolve the high rates of cotton-based products and at ...
Characterization And Culture Of Snow Alga Chlamydomonas Nivalis From Antarctica
(Central University of Punjab, 2018)
The snow alga Chlamydomonas nivalis is the reason of colouring the snow orange-red. For current study sample was collected from Dalk Glaciers, Larsmann hills, Eastern Antarctica. This is the most studied alga of snow-fields ...
Isolation And Culturing Of Photobionts From Antarctic Lichen
(Central University of Punjab, 2018)
Lichen is the symbiotic association in between algal and fungal partner. Lichens
having various economic importance. The main objective is to isolate and culture of
the photobionts from the lichen samples collected from ...
To Study Callus Induction from Explants of Nicotiana tabacum
(Central University of Punjab, 2018)
Due to a great importance of callus most of the work has been carried out on regeneration aspect of callus including somatic embryogenesis, which is very important aspect of plant tissue culture and crop improvement. A ...
Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
(Springer, 2018)
Purpose
Despite a growing body of evidence indicating a potential efficacy of the anti-diabetic metformin as anti-cancer agent, the exact mechanism underlying this efficacy has remained largely unknown. Here, we aimed at ...