Browsing Pharmacology-Research Publications by Title
Now showing items 1-20 of 122
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1,3-Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules
(John Wiley and Sons Inc, 2023-10-16)Heterocyclic compounds form an important part of wide range of biologically active molecules. The heteroatom provides them specificity for various receptors. 1,3-oxazine has been considered as a privileged scaffold in many ... -
Acute toxicity assessment of methanolic extract of Zingiber roseum (Roscoe.) rhizome in swiss albino mice
(Elsevier B.V., 2023-03-25)Introduction: The rhizomes of Zingiber roseum plant have been used in traditional medicine to treat several ailments. Regardless of worth, no research has accounted its toxicity potential. So, the study was designed to ... -
Advances in therapeutic applications of silver nanoparticles
(Elsevier Ireland Ltd, 2023-06-01)Nanotechnology is one of the most appealing area for developing new applications in biotechnology and medicine. For decades, nanoparticles have been extensively studied for a variety of biomedical applications. Silver has ... -
Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
(John Wiley and Sons Inc, 2023-10-04)mRNA vaccines have long been recognized for their ability to induce robust immune responses. The discovery that mRNA vaccines may also contribute to antitumor immunity has made them a promising therapeutic approach against ... -
Animal models of attention-deficit hyperactivity disorder (ADHD)
(John Wiley and Sons Inc, 2021-01-15)Attention-deficit hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by three primary symptoms hyperactivity, attention deficit, and impulsiveness, observed in both children and adults. ... -
Animal models of Huntington�s disease and their applicability to novel drug discovery and development
(Taylor and Francis Ltd., 2023-04-12)Introduction: Huntington�s disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of the HD-causing gene prompted the creation ... -
Antifungal synergistic effects and anti-biofilm formation activities of some bioactive 2,3-dihydro-1,5-benzoxazepine derivatives
(Springer Science and Business Media Deutschland GmbH, 2022-12-26)Benzoxazepines constitute a significant class of organic compounds extensively described in the literature. Several derivatives with pharmacological properties have been produced due to the semi-rigid azepine scaffold, ... -
Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
(Editions de Sante, 2023-06-08)Deficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of ... -
Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish
(Elsevier Ireland Ltd, 2021-08-19)Ethnopharmacological relevance: Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic ... -
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
(John Wiley and Sons Inc, 2023-05-03)The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered ... -
Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics
(MDPI, 2022-04-08)Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes ... -
Apoptosis in Alzheimer�s disease: insight into the signaling pathways and therapeutic avenues
(Springer, 2023-04-26)Alzheimer�s disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-? (A?) protein resulting in synaptic loss and apoptosis. A? and tau deposition trigger apoptotic pathways that result in ... -
Apoptotic Cell Death in Cardiomyocytes Induced by Hypoxia from Cobalt Chloride Is Hastened by SGLT-1 Inhibition
(Mary Ann Liebert Inc., 2023-09-19)Introduction: Myocardial ischemia is responsible for the deaths of millions of people every year. Cardiac hypoxia reduces the efficiency with which the heart muscle pumps blood. When one or more of the coronary arteries ... -
Bacillus calmette gaurine vaccine ameliorates the neurotoxicity of quinolinic acid in rats via the modulation of antioxidant, inflammatory and apoptotic markers
(Elsevier B.V., 2023-05-11)A mutation in the Huntingtin gene causes �Huntington's disease, which presents as a motor and behavioral impairment. Due to the limited drug therapy for this disease, scientists are constantly searching for newer and ... -
Bacillus Calmette-Gu�rin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats
(2023-11-20)Tardive dyskinesia (TD) is a hyperkinetic movement disorder that displays unusual involuntary movement along with orofacial dysfunction. It is predominantly associated with the long-term use of antipsychotic medications, ... -
The beneficial effect of rice bran extract against rotenone-induced experimental parkinson�s disease in rats
(Bentham Science Publishers, 2021-02-12)Background: Neurodegenerative diseases have become an increasing cause of various disabilities worldwide, followed by aging, including Parkinson�s disease (PD). Parkinson�s disease is a degenerative brain disorder distinguished ... -
Berberine Ameliorate Haloperidol and 3-Nitropropionic Acid-Induced Neurotoxicity in Rats
(Springer, 2022-07-25)Berberine due to its antioxidant properties, has been used around the globe significantly to treat several brain disorders. Also, oxidative stress is a pathological hallmark in neurodegenerative diseases like Huntington�s ... -
Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and i n vitro evaluation
(Newlands Press Ltd, 2023-02-07)Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & ... -
Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis
(Elsevier Ltd, 2021-11-22)Polysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of ... -
Blockade of protease-activated receptor 2 (PAR-2) attenuates vascular dyshomeostasis and liver dysfunction induced by dengue virus infection
(Churchill Livingstone, 2022-06-27)The World Health Organization (WHO) recognizes dengue infection as a major public health concern in tropical and subtropical countries. Dengue infection is recognized as the second most deadly vector-borne disease in the ...