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Exploring the Potential Role of Nf-Kb Signaling Cascade in Stress Adaptation
(Walsh Medical Media, LLC, 2021-12-22)
The present study aimed to investigate the role of NF-kB signaling in stress adaptation during exposure of repeated immobilization stress of varying duration in mice. Animals were subjected to two paradigms of immobilization ...
Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms
(John Wiley and Sons Inc, 2023-07-04)
Ephrins are protein ligands that act through the tyrosine kinase receptor family, Eph receptors. The role of ephrin/Eph in the critical processes involved in the development of the nervous system, including axon guidance ...
Exploring the role of cAMP in gabapentin-mediated pain attenuating effects in chroniconstriction injury model in rats
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2022-06-07)
It has been shown that an increase in cAMP leads to pain sensitization and gabapentin is shown to decrease cAMP levels. However, the impact of drugs modulating cAMP levels on analgesic actions of gabapentin is not studied. ...
Demystifying the dual role of the angiotensin system in neuropathic pain
(Churchill Livingstone, 2022-05-26)
Neuropathic Pain is caused by damage to a nerve or disease of the somatosensory nervous system. Apart from the blood pressure regulating actions of angiotensin ligands, studies have shown that it also modulates neuropathic ...
Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice
(John Wiley and Sons Inc, 2023-01-17)
Sepsis-induced myocardial injury is a consequence of septicemia and is one of the major causes of death in intensive care units. A serum glycoprotein called fetuin-A is secreted largely by the liver, tongue, placenta, and ...
Insights into receptor tyrosine kinases signaling in neurodegenerative disorders: opportunities and translational perspectives
(Elsevier, 2023-07-06)
Receptor tyrosine kinases (RTKs) are a group of membrane-bound receptors comprising of extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. RTKs play a crucial role in various ...
Exploring the ameliorative potential of Bacopa monnieri in acetic acid induced ulcerative colitis in mice
(Taylor and Francis Ltd., 2023-07-10)
The aim of the present study was to evaluate the role of Bacopa monnieri in acetic-acid-induced ulcerative colitis in mice. Acetic acid (3%v/v, in 0.9% saline) was infused intrarectally to induce ulceration in mice. ...
Molecular Mechanism of Beneficial Effects of Probiotics in Alcohol-Induced Liver Disorder
(Springer Nature, 2022-05-04)
Regular consumption of alcohol remains a predominant cause of a variety of hepatic disorders. There exist many alcohol-induced liver diseases including steatosis, steatohepatitis, and cirrhosis. Microflora of the gut has ...
A focus on Rho/ROCK signaling pathway: An emerging therapeutic target in depression
(Elsevier B.V., 2023-03-08)
Depression is the most common mental health disorder worldwide; however, the exact cellular and molecular mechanisms of this major depressive disorder are unclear so far. Experimental studies have demonstrated that depression ...
Investigations on Rho/ROCK signaling in post-traumatic stress disorder-like behavior in mice
(Elsevier B.V., 2023-02-14)
Post-Traumatic Stress Disorder (PTSD) is a chronic condition that occurs in response to a traumatic event, and consequently, enhances the threat sensitivity. Rho/ROCK signaling has been implicated in the consolidation of ...