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A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease
(Bentham Science Publishers, 2022-03-17)
Parkinson's disease is a chronic and gradually progressive neurodegenerative disorder trig-gered due to the loss of dopamine-releasing neurons in the region of substantia nigra pars compacta characterized by the motor ...
Mitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disorders
(Elsevier, 2022-03-18)
Mitochondria are known to be the powerhouse of the cell. Its dysfunction leads to several alterations in cellular physiology. Mitochondrial dysfunction is a well-documented process in the pathophysiology of neurodegeneration ...
Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2022-12-16)
Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains ...
Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
(Springer Science and Business Media Deutschland GmbH, 2023-07-17)
There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing cognitive deficiencies in females with estrogen insufficiency. Daidzein, a ...
Quercetin Exhibits ?7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents
(Springer, 2021-09-23)
The objective of the present study was to investigate the ?7nAChR-mediated Nrf2-dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial toxicity in Alzheimer�s disease (AD)-like rats. STZ ...
Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish
(Elsevier Ireland Ltd, 2021-08-19)
Ethnopharmacological relevance: Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic ...
Various Cellular and Molecular Axis Involved in the Pathogenesis of Asthma
(Springer Nature, 2021-07-02)
Asthma is a chronic inflammatory disease described by impaired lung function, airway hyperresponsiveness, episodic wheezing, and dyspnea. Asthma prevalence has risen drastically, and it is estimated that more than 339 ...
Transferrin decorated PLGA encumbered moxifloxacin nanoparticles and in�vitro cellular studies
(Taylor and Francis Ltd., 2023-03-05)
Purpose: Complicated intra-abdominal infection (cIAI) management involves administering antibiotics that destroy the cell wall and the genesis of bacterial lipopolysaccharide (LPS). During the infectious state, the expression ...
Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and i n vitro evaluation
(Newlands Press Ltd, 2023-02-07)
Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & ...
Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders
(Wiley-Hindawi, 2023-10-12)
Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological ...