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Gene therapy: Comprehensive overview and therapeutic applications
(Elsevier Inc., 2022-02-03)
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where the desired gene in the form of plasmids and viral ...
L-Methionine prevents ?-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
(Elsevier GmbH, 2021-12-03)
L-Methionine (L-Met) is an essential sulphur-containing amino acid having a vital role in various key cellular processes. Here we investigated the effect of L-Met on streptozotocin-induced ?-cell damage model of diabetes ...
Spotlight on liver macrophages for halting liver disease progression and injury
(Taylor and Francis Ltd., 2022-10-07)
Introduction: Over the past two decades, understanding of hepatic macrophage biology has provided astounding details of their role in the progression and regression of liver diseases. The hepatic macrophages constitute ...
Antimicrobial and anti-viral effects of selenium nanoparticles and selenoprotein based strategies: COVID-19 and beyond
(Editions de Sante, 2023-06-08)
Deficiency of selenium (Se) has been described in a significant number of COVID-19 patients having a higher incidence of mortality, which makes it a pertinent issue to be addressed clinically for effective management of ...
A comparative study of colored wheat lines across laboratories for validation of their phytochemicals and antioxidant activity
(Academic Press, 2023-06-07)
With aim of assessing inter-laboratory variations, phytochemical and antioxidant analysis of seventeen wheat lines were carried out in three well-equipped Indian laboratories viz- National Agri-Food Biotechnology Institute ...
Gut microbiota dysbiosis and Huntington's disease: Exploring the gut-brain axis and novel microbiota-based interventions
(Elsevier Inc., 2023-06-24)
Huntington's disease (HD) is a complex progressive neurodegenerative disorder affected by genetic, environmental, and metabolic factors contributing to its pathogenesis. Gut dysbiosis is termed as the alterations of ...
Protective role of natural products and bioactive compounds in multiple sclerosis
(Elsevier, 2023-06-16)
Multiple sclerosis (MS), a chronic multifactorial disease characterized by progressive demyelination and neurodegeneration, is rising rapidly in young adults. The pathology of the disease is not yet understood completely. ...
Advances in therapeutic applications of silver nanoparticles
(Elsevier Ireland Ltd, 2023-06-01)
Nanotechnology is one of the most appealing area for developing new applications in biotechnology and medicine. For decades, nanoparticles have been extensively studied for a variety of biomedical applications. Silver has ...
Is highly expressed ACE 2 in pregnant women �a curse� in times of COVID-19 pandemic?
(Elsevier Inc., 2020-10-28)
Angiotensin-converting enzyme 2 (ACE 2) is a membrane-bound enzyme that cleaves angiotensin II (Ang II) into angiotensin (1�7). It also serves as an important binding site for SARS-CoV-2, thereby, facilitating viral entry ...
Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research
(Springer Nature, 2022-05-30)
Zebrafish is a powerful platform in the modern era of phenotype-based drug discovery and eminent vertebrate model to study disease progression and its pathophysiology. Zebrafish possess several advantages over rodent model ...