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Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
(Elsevier Inc., 2022-08-01)
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered one of the most common causes of dementia worldwide, accounting for about 80 % of all dementia cases. AD is manifested by the extraneuronal ...
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
(Elsevier B.V., 2023-09-13)
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy requirements, substantial calcium (Ca2+) fluctuation, and neurotransmitter release at the synapse. To provide a continuous energy ...
Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects
(Elsevier Inc., 2023-07-29)
Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to memory loss and cognitive impairment over time. It is characterized by protein misfolding as well as prolonged cellular stress, such as ...
Insights into receptor tyrosine kinases signaling in neurodegenerative disorders: opportunities and translational perspectives
(Elsevier, 2023-07-06)
Receptor tyrosine kinases (RTKs) are a group of membrane-bound receptors comprising of extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. RTKs play a crucial role in various ...
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
(John Wiley and Sons Inc, 2023-05-03)
The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered ...
Apoptosis in Alzheimer�s disease: insight into the signaling pathways and therapeutic avenues
(Springer, 2023-04-26)
Alzheimer�s disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-? (A?) protein resulting in synaptic loss and apoptosis. A? and tau deposition trigger apoptotic pathways that result in ...