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Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS
(Elsevier B.V., 2021-11-30)
Epilepsy is a neurological disease that transpires due to the unusual synchronized neuronal discharge within the central nervous system, which drives repetitious unprovoked seizures. Nicotinamide adenine dinucleotide ...
Mitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disorders
(Elsevier, 2022-03-18)
Mitochondria are known to be the powerhouse of the cell. Its dysfunction leads to several alterations in cellular physiology. Mitochondrial dysfunction is a well-documented process in the pathophysiology of neurodegeneration ...
Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review
(Elsevier B.V., 2022-10-30)
Background: Ferulic acid is a polyphenolic phytoconstituent synthesized from the metabolism of amino acids phenylalanine and tyrosine found in fruits and vegetables. Neurodegenerative disorders have been a thorn in the ...
Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
(Springer Science and Business Media Deutschland GmbH, 2022-12-05)
Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock for the management of malaria globally. Recent works have implied that they could be used to manage ...
An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development
(Springer, 2023-02-04)
Animal models are used to better understand the various mechanisms involved in the pathogenesis of diseases and explore potential pathways that will aid in discovering therapeutic targets. 3-Nitropropionic Acid (3-NPA) is ...
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA
(Taylor and Francis Ltd., 2023-11-16)
Introduction: Recent neuroscience breakthroughs have shed light on the sophisticated relationship between calcium channelopathies and movement disorders, exposing a previously undiscovered tale focusing on the Ryanodine ...