miR-590�5p: A double-edged sword in the oncogenesis process
Date
2022-06-12Author
Barwal, Tushar Singh
Singh, Neha
Sharma, Uttam
Bazala, Sonali
Rani, Medha
Behera, Alisha
Kumawat, Ram Kumar
Kumar, Pawan
Uttam, Vivek
Khandelwal, Akanksha
Barwal, Jyoti
Jain, Manju
Jain, Aklank
Metadata
Show full item recordAbstract
Accumulating evidence suggests the critical role of miR-590�5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590�5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590�5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590�5p to resolve this apparent paradox. We have also described the involvement of miR-590�5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590�5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. � 2022
Journal
Cancer Treatment and Research Communications
Access Type
Open Access