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A cascade A3 coupling strategy towards the regioselective synthesis of ?-carboline N-fused pyrrole derivatives with pyridine tethers

dc.contributor.authorVaishali, None
dc.contributor.authorMalakar, Chandi C.
dc.contributor.authorSingh, Virender
dc.date.accessioned2024-01-21T10:33:05Z
dc.date.available2024-01-21T10:33:05Z
dc.date.issued2022-12-01T00:00:00
dc.identifier.issn11440546
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/3260
dc.description.abstractA potential three component reaction strategy has been devised to generate nature inspired ?-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in high yields via a one-pot cascade regioselective reaction of diverse Kumujian C, 2-aminopyridines and alkyne derivatives under Cu(ii)-catalysis. A library of 32 novel indolizino[8,7-b]indole derivatives with pyridine tethers has been developed. The current protocol offers excellent regioselectivity, high atom-economy and significant structural diversity. � 2023 The Royal Society of Chemistry.en_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectBiomimetic processesen_US
dc.subjectCopper compoundsen_US
dc.subjectRegioselectivityen_US
dc.subjectScaffoldsen_US
dc.subjectSynthesis (chemical)en_US
dc.subjectTetherlinesen_US
dc.subjectalkyne derivativeen_US
dc.subjectbeta carboline derivativeen_US
dc.subjectcopperen_US
dc.subjectindole derivativeen_US
dc.subjectindolizino[8,7 b]indole derivativeen_US
dc.subjectpyridineen_US
dc.subjectpyrrole derivativeen_US
dc.subjectunclassified drugen_US
dc.subject2-Aminopyridineen_US
dc.subjectFused pyrroleen_US
dc.subjectHigher yielden_US
dc.subjectOne poten_US
dc.subjectPyrrole derivativesen_US
dc.subjectReaction strategiesen_US
dc.subjectRegioselective reactionsen_US
dc.subjectRegioselective synthesisen_US
dc.subjectThree component reactionsen_US
dc.subject?-carbolineen_US
dc.subjectArticleen_US
dc.subjectcatalysisen_US
dc.subjectchemical structureen_US
dc.subjectcross coupling reactionen_US
dc.subjecteconomic aspecten_US
dc.subjectone pot synthesisen_US
dc.subjectregioselectivityen_US
dc.subjectsynthesisen_US
dc.subjectPyridineen_US
dc.titleA cascade A3 coupling strategy towards the regioselective synthesis of ?-carboline N-fused pyrrole derivatives with pyridine tethersen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/d2nj04620b
dc.identifier.urlhttp://xlink.rsc.org/?DOI=D2NJ04620B
dc.title.journalNew Journal of Chemistryen_US
dc.type.accesstypeClosed Accessen_US


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