Dihydropyrimidinone scaffold and potential therapeutic targets
Date
2023-08-25Author
Kumar, Adarsh
Singh, Ankit Kumar
Vijayan, Veena
Singh, Harshwardhan
Verma, Amita
Kumar, Pradeep
Metadata
Show full item recordAbstract
Dihydropyrimidine is the most important heterocyclic ring system involved in the synthesis of RNA and DNA. Dihydropyrimidines were produced synthetically by multicomponent reactions such as the Biginelli reaction. Because of their remarkable biological characteristics, dihydropyrimidinones (DHPMs) have drawn considerable attention in recent years. In this chapter, we have described the synthetic and pharmacological properties of DHPMs employing multicomponent synthesis. It emphasizes also widespread pharmaceutical applications of DHPMs, including antitubercular, antifilarial, antihypertensive, antiinflammatory, anticancer, antifungal, antibacterial, anti-HIV, antihyperglycemic, anti-SARS, analgesic, antioxidant, anticonvulsant, anti-Alzheimer�s and antihepatitis properties. This chapter will be of immense importance for the scientists working in this area. � 2023 Elsevier Inc. All rights reserved.
Journal
Dihydropyrimidinones as Potent Anticancer Agents: Medicinal Chemistry Perspective
Access Type
Closed Access