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    Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

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    Date
    2013
    Author
    Baviskar, Ashish T.
    Banerjee, Uttam C.
    Gupta, Mukesh
    Singh, Rajveer
    Kumar, Sunil
    Gupta, Manish K.
    Kumar, Sanjeev
    Rout, Satish K.
    Khullar, Madhu
    Singh, Sandeep
    Kumar, Raj
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    Abstract
    Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented. ? 2013 Elsevier Ltd. All rights reserved.
    Journal
    Bioorganic and Medicinal Chemistry
    URI
    http://210.212.34.21/handle/32116/403
    URL
    https://www.sciencedirect.com/science/article/pii/S0968089613006275?via%3Dihub
    DOI
    10.1016/j.bmc.2013.07.016
    Collections
    • Human Genetics and Molecular Medicine-Research Publications [137]
    • Pharmaceutical Sciences and Natural Products-Research Publications [135]
    • Plant Sciences-Research Publications [160]

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    Contact Us | Send Feedback
    Initiatives by University Library 
    Central University of Punjab