Caspase-mediated regulation of the distinct signaling pathways and mechanisms in neuronal survival
Date
2022-06-16Author
Khan, Heena
Bangar, Annu
Grewal, Amarjot Kaur
Bansal, Puneet
Singh, Thakur Gurjeet
Metadata
Show full item recordAbstract
Caspases are intimately associated with altering various signaling pathways, resulting in programmed cell death or apoptosis. Apoptosis is necessary for the normal homeostasis of cells and their development. The untoward activation of apoptotic pathways indirectly or directly results in pathologies of various diseases. Identifying different caspases in apoptotic pathways directed the research to develop caspase inhibitors as therapeutic agents. However, no drug is available in the market that targets caspase inhibition and produces a therapeutic effect. Here, we will shed light on the role of caspases in the number of neuronal disorders and neurodegenerative diseases. The article reviews the findings about the activation of various upstream mechanisms associated with caspases in neurodegenerative disorders along with the recent progress in the generation of caspase inhibitors and the challenge faced in their development as therapeutic agents for neurological indications. � 2022 Elsevier B.V.
Journal
International Immunopharmacology
Access Type
Closed Access