Chemical composition, in�vitro and in silico evaluation of essential oil from Eucalyptus tereticornis leaves for lung cancer
Date
2022-08-08Author
Anju
Kumar, Amit
Yadav, Poonam
Navik, Umashanker
Jaitak, Vikas
Metadata
Show full item recordAbstract
Chemical composition of the essential oil (EO) of Eucalyptus tereticornis leaves was studied by gas chromatography�mass spectrometry. Forty-five constituents were identified in the oil hydrodistilled from the sample collected from Ghudda Village, Bathinda (Pb), India of which eucalyptol (34.39%) and ledol (9.92%) were the major constituents. In vitro antioxidant and anticancer potential of EO was analysed by DPPH 2,2-diphenylpicrylhydrazyl (DPPH) and MTT assay. The percentage free radical scavenging activity was found to be 63.77%. The antiproliferative activity was analysed using MTT assay in adenocarcinomic human alveolar basal epithelial A549 cancer cell line and showed IC50 value of 47.14 �g/ml. In silico study of EO, constituents were performed using Maestro 12.9 against EGFR (PDB ID-2RGP). Five constituents from EO showed high dockscore as compared to standard Mobicertinib which indicated the effectiveness of oil constituents against lung cancer. � 2022 Informa UK Limited, trading as Taylor & Francis Group.
Journal
Natural Product Research
Access Type
Open Access