Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
Date
2022-08-18Author
Gundu, Chayanika
Arruri, Vijay Kumar
Yadav, Poonam
Navik, Umashanker
Kumar, Ashutosh
Amalkar, Veda Sudhir
Vikram, Ajit
Gaddam, Ravinder Reddy
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Show full item recordAbstract
Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a �molecular scissor� to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis. � 2022 by the authors.
Journal
Cells
Access Type
Open Access