Zebrafish as an emerging tool for drug discovery and development for thyroid diseases
Date
2022-09-06Author
Yadav, Poonam
Sarode, Lopmudra P.
Gaddam, Ravinder Reddy
Kumar, Puneet
Bhatti, Jasvinder Singh
Khurana, Amit
Navik, Umashanker
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Show full item recordAbstract
Zebrafish is a useful model for understanding human genetics and diseases and has evolved into a prominent scientific research model. The genetic structure of zebrafish is 70% identical to that of humans. Its small size, low cost, and transparent embryo make it a valuable tool in experimentation. Zebrafish and mammals possess the same molecular mechanism of thyroid organogenesis and development. Thus, thyroid hormone signaling, embryonic development, thyroid-related disorders, and novel genes involved in early thyroid development can all be studied using zebrafish as a model. Here in this review, we emphasize the evolving role of zebrafish as a possible tool for studying the thyroid gland in the context of physiology and pathology. The transcription factors nkx2.1a, pax2a, and hhex which contribute a pivotal role in the differentiation of thyroid primordium are discussed. Further, we have described the role of zebrafish as a model for thyroid cancer, evaluation of defects in thyroid hormone transport, thyroid hormone (TH) metabolism, and as a screening tool to study thyrotoxins. Hence, the present review highlights the role of zebrafish as a novel approach to understand thyroid development and organogenesis. � 2022 Elsevier Ltd
Journal
Fish and Shellfish Immunology
Access Type
Closed Access