Browsing Department of Pharmaceutical Sciences and Natural Products by Issue Date
Now showing items 21-40 of 298
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Imidazole based compunds: Synethesis and in vitro anticancer screening
(Central University of Punjab, 2013)Imidazole is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron rich characteristic is ... -
New approaches to target cancer stem cells: Current scenario
(2014)Resistance towards chemotherapy and radiotherapy as well as relapse of cancer is the major obstacle in the treatment of cancer. The main factor behind is cancer stem cells (CSCs) which are more resistant to conventional ... -
Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists
(Elsevier, 2014)Opioid ligands have found use in a number of therapeutic areas, including for the treatment of pain and opiate addiction (using agonists) and alcohol addiction (using antagonists such as naltrexone and nalmefene). The ... -
1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: Exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway
(Wiley-VCH Verlag, 2014)A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative ... -
SHATAVARI (ASPARAGUS RACEMOSUS WILD): A REVIEW ON ITS CULTIVATION, MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGICAL IMPORTANCE
(web of Science (Thomson Reuters), 2014)Asparagus racemosus, a climbing Ayurvedic plant, is known for its numerous activities such as hyperlipidemia, hypertension, angina, dysmenorrhea, anxiety disorders, benign prostatic hyperplasia (BPH), leucorrhoea and urinary ... -
Chemical composition and biological effects of artemisia maritima and artemisia nilagirica essential oils from wild plants of Western Himalaya
(Georg Thieme Verlag, 2014)Artemisia species possess pharmacological properties that are used for medical purposes worldwide. In this paper, the essential oils from the aerial parts of Artemisia nilagirica and Artemisia maritima from the western ... -
Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/ Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
(ACS Publications, 2014)Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy ... -
4,5-Dihydro-1H-pyrazole: An indispensable scaffold
(Informa Healthcare, 2014)Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles ... -
Synthesis and xanthine oxidase inhibitory activity of 5,6 dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives
(Elsevier, 2014)Some 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives were rationally designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity ... -
Microwave-assisted synthesis of pyrazolo[1,5-c]quinazolines and their derivatives
(Elsevier, 2014)Microwave accelerated and expedited cyclocondensation reactions of 2-(3-aryl-1H-pyrazol-5-yl)anilines (4) with diverse aryl aldehydes/triethyl orthoformate in water/MeCN (route D) and internal cyclocondensation and ... -
Impact of ABC transporters, glutathione conjugates in MDR and their modulation by flavonoids: An overview
(2014)Overexpression of ATP-binding cassette (ABC) transporter and glutathione conjugates results in efflux of cytotoxic agent from tumor cells leading to multidrug resistance (MDR). Many MDR inhibitors have been identified but ... -
Drug target strategies in breast cancer treatment: Recent developments
(Bentham Science Publishers B.V., 2014)Breast cancer (BC) is the leading cause of death among women all over the world. Estrogen receptor (ER) based therapy is one of the major approaches to target BC and is associated with various problems such as primary as ... -
Essential Oils: New Perspectives in Human Health and Wellness.
(Hindawi, 2014)Essential oils are natural products, derived from aromatic plants, traditionally used all over the world for disinfection, as anti-inflammatory, relaxing, and stimulating substances, and with potential and modern exploitation ... -
Invitro anti-mutagenic potential of potentilla fulgens: A western himalayan plant
(Informatics Publishing Limited, 2014)Invitro anti-mutagenic potential of different extracts/fractions of Potentilla fulgens has been made by an Ames histidine reversion assay using TA98 and TA100 tester strains of Salmonella typhimurium against the direct-acting ... -
Phytochemical investigation of natural sweetener from stevia rebaudiana (Bartoni)
(Central University of Punjab, 2014)S. rebaudiana is an important plant because of the high concentration of steviol glycosides (SGs). Sugars and artificial sweeteners, which are used in general as well as in pharmaceutical field have shown multiple toxic ... -
Synethesis of some piperazine containing scataining scaffolds as potential MAO inhibitors
(Central University of Punjab, 2014)Ficus benghalensis and Ficus religiosa commonly known as Banyan and Peepal trees (or Bodhi) respectively, are important tropical trees that are being grown and traditionally revered throughout Indian subcontinent for ... -
Anticancer activity of cassia fistula linn through invitro and insilicoapproach
(Central University of Punjab, 2014)Cassia fistula L. (Leguminoseae) is a plant species called "Aragvadha" that means "disease killer". C. fistula consists of plethora of medicinal properties. A detailed discussion is depicted of the therapeutic potential ... -
Design and synethesis of APE1 inhibitors as putative anticancer agents
(Central University of Punjab, 2014)Success in chemotherapy has not been attained completely yet and has remained a worried issue from years. Various reasons drive this failure, but the much talked about is failure due to emergence of resistance to ... -
Design and synethesis of putative anti-cancer agents using hybrid molecular approach
(Central University of Punjab, 2014)A Hybrid drug involves the unification of two drug pharmacophores in one single molecule. The hybrid drugs are designed to interact with multiple targets or to intensify its effect through action on another bio target as ...